Virotherapy Pipeline

More. Better.

Myxoma virotherapy is designed to expand the effectiveness of immunotherapy.

Our goal is to achieve the greatest therapeutic benefit from immunotherapy for more cancer patients. While certain immunotherapies, such as checkpoint inhibitors, have shown great potential to eliminate cancer, only a small percentage of patients are eligible, of which a subset achieve a durable response. Furthermore, it is difficult to cost-effectively identify which patients will respond. To create an economic and logistical path to broaden the use of immunotherapies, OncoMyx is leveraging the unique advantages of myxoma virus, as an oncolytic immunotherapy, to target mechanisms that are common to a number of cancers. With this pan-tumor approach, our pipeline of myxoma virotherapies are designed to boost the number of cancer patients who could benefit from immunotherapies.

Pipeline.

Our pipeline of myxoma virotherapies for the treatment of cancer are specifically engineered to improve the inherent ability of the myxoma virus to selectively target and destroy cancer cells and are ideal for combining with other immunotherapies to improve therapeutic response. Our myxoma virotherapies can be multi-armed to activate multiple steps in the cancer immunity cycle as well as create a precision medicine approach for pan-tumor targeting. We are advancing our multi-armed myxoma virotherapies in combination with checkpoint inhibitors and other immunotherapy approaches. As myxoma virus is one of the few oncolytic immunotherapies that can be delivered intravenously, our myxoma virotherapy is designed to create wider therapeutic and longer dosing windows for a durable response.

OM101 Solid Tumors Preclinical
Multi-armed, checkpoint inhibitor combo; preclinical IV efficacy
OM102, 103... Solid Tumors Preclinical
Built off OM 101 platform
OM201, 202... Solid Tumors Discovery
Undisclosed organ/cancer site targeting approaches
OM301 Multiple Myeloma Discovery
Undisclosed Bispecific (BiKe)
OM302 AML Discovery
Undisclosed

Four Potential Areas of Clinical Opportunity

IO Sensitive Indications

Increase response in responders

Post IO Indications
Secondary Resistant

Re-sensitize tumors to IO

IO Resistant Tumors

Make cold tumors sensitive to IO

Niche Indications

Rapid path to approval

We’ve identified four potential areas of clinical opportunity for myxoma virotherapies.

  • For immunotherapy sensitive and approved indications where response rates average 10-15%, myxoma virotherapy could expand the percentage of patients who respond. 
  • For patients who initially responded to other immunotherapy approaches but then became resistant, myxoma virotherapy could re-sensitive the tumors to immunotherapy. 
  • For “cold tumors,” which are resistant to other immunotherapy approaches, myxoma virotherapy could sensitize those tumors to immunotherapy.
  • Finally, we could personalize our myxoma virotherapies for niche indications, which could provide a rapid path to approval.